
EPITHELIUM
Meesmann's corneal dystrophy
- autosomal dominant
 - presents in 1st decade and progresses into adulthood
 - diffusely distributed intraepithelial cysts that are usually concentrated in the interpalpebral zone
 - in severe cases cysts can rupture on surface causing irritation and photophobia (use bandage CL)
 
EBMD (Map-Dot fingerprint dystrophy or Cogan's microcystic epithelial dystrophy)
- autosomal dominant or due to trauma or surgery
 - geographic epithelial changes (maps), opaque irregularities (dots) or concentric irregular lines (fingerprints)
 - results from a thickened basement membrane
 - can result in recurrent corneal erosions (bandage CL)
 - Muro 128 during the day or ung at night may be necessary for up to 3 months (if this fails to prevent recurrent erosions, may need anterior stromal puncture or PTK
 
BOWMAN'S LAYER
Reis-Buckler's corneal dystrophy
- autosomal dominant, presents 1st decade of life
 - subepithelial reticular changes that progress until middle age
 - may opacify or induce irregular astigmatism
 - may have erosions (bandage CL)
 
STROMA
Granular dystrophy
- autosomal dominant, presents 1-2nd decade of life
 - grayish white opacities form in the central (almost never periphery) anterior stroma with clear intervening space
 - lesions can become larger and more numerous with stromal hazing
 
Macular dystrophy
- rarest (autosomal recessive)
 - anterior stroma becomes hazy in 1st decade, progressing to opacified lesions
 - more likely to affect peripheral cornea
 - worse visual prognosis
 
Lattice dystrophy
- autosomal dominant, 1st decade
 - refractile lines in the anterior stroma which eventually branch and develop deeper into stroma (lattice design)
 - prone to erosions (bandage CL)
 
ENDOTHELIUM
Posterior polymorphous dystrophy (PPD)
- vesicles deep into the cornea that may be isolated, mutiple/coalesced, or broad bands/train tracks
 - may apear blister-like and have a gray white halo aroudn them
 - increased risk of glaucoma
 
Fuch's endothelial dystrophy
- guttata (refractice excrescenses) on posterior cornea due to abnormal functioning endothelial cells (from aging, trauma or inflammation)
 - Fuch's is diagnosed when nonfunctioning endo causes corneal edema
 - vision worse upon awakening
 - muro 128 gtts and ung
 - extreme epithelial edema may cause bulae with pain and photophobia (bandage CL)
 - usually have cataracts
 - cataract surgery may cause a dramatic worsening of Fuch's 
 
BANDAGE CL
- use steeper curve (unless there is no mvmt then use flatter one)